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Subacute toxicity studies in dogs for 4 months at 480 mg/kg each day showed no specific adjustments; at 960 mg/kg, two out of 8 died with proof of circulatory collapse. This vast margin of safety is significant when compared with chlordiazepoxide HCl, which showed nonspecific modifications in 6 canine at 80 mg/kg.Paradoxical reactions, which includ